The human body has an amazing self-healing system that repairs damaged cells on a daily basis. This is called regeneration. With injury or trauma, the body’s natural immune and restorative properties sometimes can not repair the degree of injury the body has sustained either through trauma or natural wear and tear. In these cases, using innovative orthobiologic treatments can be very helpful to achieve natural healing. With cutting-edge science physicians are able to provide non-surgical options for patients with orthopedic injury or damage. Orthobiologic modalities are defined as living cells or other substances or materials that can affect the healing of bone, cartilage, tendon, ligament, muscle, or nerve. These therapies currently include stem cells, growth factors, exosomes, amniotic fluid, fat grafts, cytokines, pericytes and platelet rich plasma (PRP). Regenerative treatments continued to evolve and advanced science is leading us to determine the best sources and protocols to enhance healing.